The iridium tipped OEM spark plugs in the VTEC 3.5 liter V6 engine of a 1st generation (2003, 2004, 2005, 2006, 2007 & 2008) Honda Pilot SUV can last up to 100,000 miles, but they should be checked well before that mileage. To view my DIY tutorial for checking or changing the spark plugs (with the compatible replacement part numbers), click on the text link or thumbnail image below.