The coolant / antifreeze in a 1st generation 2001, 2002, 2003, 2004, 2005 & 2006 Acura MDX with the 3.5L VTEC V6 engine should be changed after 120,000 miles or 10 years and then every 60,000 miles (5 years) after that. Check out my DIY tutorial for draining the radiator and the engine block by clicking on the text link or thumbnail image below.